Daily Agenda

L02 –John Gleeson, Senior Scientist, Merck
Development, Validation, and Implementation of Intestinal Cell Models to Guide Oral Peptide Formulation Design

L03 –Severin Schneebeli, Associate Professor, Purdue University
The Molecular Basis of Oral Peptide Delivery with Permeation Enhancers

L04 - YI1 –Laura M. Poller, Graduate Student, ETH Zürich
Collagen Cross-Linking: Structure and Sequence Selectivity of Lysyl Oxidase-Like 2

L05 –Marco Pires, Professor and Director of Graduate Studies, University of Virginia
Systematic Determination of the Impact of Structural Edits on Accumulation into Mycobacteria

L06 –Joshua Kritzer, Professor, Tufts University
Chemical Biology Approaches for Measuring Intracellular Drug Delivery

L07 –Michelle Arkin, Professor, Univ. of California, San Francisco
Peptide/protein Complexes as Models for Protein/Protein Interactions in Drug Discovery

L08 –Jaehoon Yu, Ph.D., CAMP Therapeutics
Mitochondrial Targeting α-Helical Amphipathic Peptides As Drug Candidates for Sarcopenia

L09 - YI2 –Caroline Almeida, Graduate Student, Federal University of Rio de Janeiro and UC Merced
Transcriptional Regulation of Aspergillus nidulans Biofilms from Environmental and Clinical Isolates Exposed to Pisum sativum Defensin 2

L10 –David Lawrence, Distinguished Professor, University of North Carolina
Peptides as Therapeutic Partners: From Drug Delivery to Molecular Sentinels

L11 –Jun Ohata, Assistant Professor, North Carolina State University
Potential Roles of Solid-State Reactivity of Dipeptides in Prebiotic Polypeptide Synthesis

L12 –Gong Chen, Professor, Nankai University
Simple C1 Chemistry for Peptide Modification

L13 –Lara Malins, Professor, Australian National University
Advances in Late-Stage Peptide Modification Chemistry: Inspiration from Nature

L14-YI3 –Zhenquan Sun, Postdoctoral Scholar, University of Chicago
Chemical Synthesis of Difficult Peptide and Protein by N,O/S-Benzylidene (thio)Acetals (NBA) Strategy

L15 –Timothy Reichart, Elliott Assistant Professor of Chemistry, Hampden-Sydney College
Total Chemical Synthesis of a 97-Amino Acid Target-Binding Monobody via Cysteine-Free Conformationally-Assisted Ligation

L16-AW –Elizabeth, 'Betsy,' Parkinson, Assistant Professor, Purdue University
Utilizing Bioinformatics, Biocatalysis, and Synthetic Chemistry to Access Natural Product-Inspired Cyclic Peptides

L17-AW –Dek Woolfson, Professor, University of Bristol
From Peptides to Proteins to Functions by Design

L18 –Beate Koksch, Professor, Freie Universität Berlin
Fluoropeptides as Biodegradable Biopolymers

L19-YI4 –Ashutosh Agrahari, Graduate Student, Purdue University
Growth Mechanism of Coiled-Coil Peptide Nanocrystals and their Application for Intracellular Delivery of Proteins

L20 –Vincent P. Conticello, Professor, Emory University
Peptide-Based Nanomaterials: Progress from Structural Analysis to Design

L21 –Tania Lopez-Silva, Postdoctoral Fellow, National Cancer Institute
Peptide Hydrogels Control Neutrophil Extracellular Trap, NET, Formation in vivo with Locoregional Precision

L22 - AW –Akif Tezcan, Professor of Chemistry and Biochemistry, University of California, San Diego
Design of Out-of-Equilibrium Biomolecular Assemblies

L23 –Junfeng Zhao, Professor, Guangzhou Medical University
Peptide Synthesis Using Unprotected Amino Acids

L24 –Anna Maria Papini, Professor, University of Florence
Advancing Sustainable Peptide Synthesis: Green Strategies for Scalable and Efficient Automatised Solid-Phase Manufacturing

L25 - YI5 –Sikabwe Noki, Postdoctoral Research Fellow, University of KwaZulu-Natal
"Base Labile" Safety Catch Linker. Synthesis and Applications in SPPS in a Green Context

L26 –Francesco Merlino, Assistant Professor, University of Naples Federico II
Ultrasound-Powered Sustainable Chemical Synthesis of Bioactive Peptides

L27 –Michael Kopach, Associate Vice President, Eli Lilly
Retatrutide: A Novel Triagonist for Metabolic Disorders and CMC Advancements

L28 –Carrie Haskell-Luevano, Professor, University of Minnesota
Paradigms for the Discovery of Unknown Naturally Occurring GPCR Ligands in Chemical Neuroscience: Melanocortins and Opioids

L29 - YI6 –Tiancheng Chen, Graduate Student, University of Georgia
C-tail Mimics of LRRK2 Downregulate Kinase Activity in Parkinson’s Disease

L30 –Aphrodite Kapurniotu, Professor, Technical University of Munich
Designed Macrocyclic Peptides as Nanomolar Inhibitors of Self- and Cross-Sseeded Amyloid Self-Assembly of Alpha-Synuclein

L31 –Federica Tucci, Principal Research Scientist, IRBM
R2R01, a Potent Long-Acting RXFP1 Peptide Agonist as Clinical Candidate in Phase 2 Studies for Cardiovascular and Renal Diseases

L32 –Robin Polt, Professor, The University of Arizona
O-Linked Glycopeptides Derived from Endogenous Neurotransmitters as a Source of Brain-Penetrant CNS Drugs for the Treatment of Stroke, mTBI and Neurodegeneration

L33 –Pascale Guiton, Assistant Professor, Santa Clara University
Inclusive Mentoring

L34 –William DeGrado, Professor, Univ. of California, San Francisco
De novo Protein Ddesign of Functional Proteins

L35 –Jutta Eichler, Professor of Medicinal Chemistry, University of Erlangen-Nurnberg
Bind & Bite: Covalently Stabilized Heterodimeric Coiled-Coil Peptides for the Site-Selective Chemical Modification of Proteins

L36 –Thu Nguyen, Ph.D. Candidate in Chemistry, New York University
A Proteomimetic Strategy for Modulation of Intrinsically Disordered Protein MYC

L37 –Kira Podolsky, Post Doctoral Research Assistant, Massachusetts Institute of Technology
A Peptide can Replace an Essential Enzyme in Yeast

L38 –Richard Bayliss, Professor of Molecular Medicine, University of Leeds
Hydrocarbon-Stapled Peptidomimetic of TACC3 Disrupts CHC Interaction and Delays Mitotic Progression

L39 –Norman Metanis, Professor, The Hebrew University of Jerusalem
Chemical Protein Synthesis as a Tool for Therapeutic Applications: The development of Mirror-Image RaPID Technology & New Insulin Analogues

L40 –Laura Kiessling, , Novartis Professor of Chemistry
Testing Immune Recognition of Modified Peptides

L41 –Andy Wilson, Professor, University of Birmingham
Understanding and Manipulating Protein-Protein Interactions of Aurora-A Kinase Employing Intrinsically Disordered Regions

L42 –Jacky C.K Ngo, Associate Professor, The Chinese University of Hong Kong
Design of a Covalent Protein-Protein Interaction Inhibitor of SRPKs to Suppress Angiogenesis and Invasion of Cancer Cells

L43 –Mark Frigerio, Vice President, Chemistry, Bicycle Therapeutics
Bicycle® Molecules as an Innovative and Unique Therapeutic Class

L44 –Laurie Parker, Professor, University of Minnesota
Using Experimental Approaches and AI-Based Structural Modeling to Understand Kinase-Substrate Interactions

L45 –Ingrid Dijkgraaf, Professor, Maastricht University
Computational Epitope Mapping and Chemical Engineering of Tick Proteins for Vaccine Development

L46 –Yu-Shan Lin, Professor - Department Chair, Tufts University
Integrating Molecular Dynamics Simulation & Machine Learning for Cyclic Peptide Structure Prediction

L47 –Ewa Lis, Chief Executive Officer, Koliber Biosciences
AI-Driven Peptide Discovery: Unlocking the Potential of Peptide Arrays for Therapeutic Development

L48 –Gaurav Bhardwaj, Assistant Professor, University of Washington
Generative Deep Learning for Accurate de novo Design of Macrocyclic Peptides

L49 –Lila Gierasch, Distinguished Professor, University of Massachusetts
How Hsp70 Molecular Chaperones Bind Substrates with Selective Promiscuity

L50 –Mark Lipton, Associate Professor, Purdue University
Eradicating HIV-1 Latency Through the Development of Dual Inhibitors of HIV-1 Protease and Histone Deacetylase 3

L51 –Ana Salome Veiga, Assistant Professor, Gulbenkian Institute for Molecular Medicine
Unveiling the Mode of Aaction of SARS-CoV-2 Putative Fusion Peptides and their Exploitation as Antiviral Targets

L52 –Gosuke Hayashi, Associate Professor, Nagoya University
Mirror-Image Monobody Targeting MCP-1 Generated via mRNA Display and Peptide Ligation

L53-AW –Philip E. Dawson, Professor, Scripps Research Institute
TBD

L54 –Richard DiMarchi, Distinguished Professor, Indiana University 
The Chemical Evolution of Peptides To Transform Human Health

L-55 –Timo Müller, Professor, Ludwig Maximilians University München
Novel Insights into Regulation of Energy and Glucose Metabolism by GIP and GIPR:GLP-1R Co-Agonists

L56 –Poanna Tran, Research Scientist, Gubra ApS
Machine Learning Guided Peptide Drug Discovery Speeds up Lead Identification as Demonstrated with Novel GLP-1R Agonists

L57 –Christoffer Clemmensen, Associate Professor, University of Copenhagen
Peptide-Based Therapeutics for Treatment of Cardiometabolic Diseases

L58-AW –Krishna Kumar, Robinson Professor of Chemistry, Tufts University
Two Bites at the Apple: Design and Repair of Peptide Therapeutics

L59 –James Nowick, Distinguished Professor, University of California, Irvine
Potent Peptide Antibiotics Against Pernicious Pathogens

L60 –Juan Del Valle, W.K. Warren Family Professor, University of Notre Dame
β-Arch Macrocycles as Functional Tau Proteomimetics

L61 –Maja Köhn, Professor, University of Bonn
Targeting Phosphatases with Peptides and Phosphomimetics

L62 –Huong Kratochvil, Assistant Professor, University of North Carolina
Going with the Flow: Proton-Selective Transport through de novo Designed Peptide Bundles

L63-AW –William Lubell, Professor, Université de Montréal
Semicarbazides as Amino Amide Surrogates in Peptide Mimicry for Treating Unmet Medical Conditions

L64 –Marcey Waters, Glen H. Elder, Jr. Distinguished Professor, University of North Carolina
Addressing the Challenge of Selective Inhibition of Histone Trimethyllysine Reader Proteins through Electrostatic Pocket Mapping

L65 –Mark Distefano, Distinguished McKnight University Professor, University of Minnesota
Synthetic Peptides and Modified Forms of Full-Length K-Ras4B, Prepared via Expressed Protein Ligation, Provide Insights into its Posttranslational Modification

L66 –Muhammad Jbara, Assistant Professor, Tel Aviv University
Cracking the Code of PTMs on Transcription Factor-DNA Interactions Using Synthetically Modified Proteins

L67 –Chi Ting, Assistant Professor, Brandeis University
Chemical Synthesis of Ribosomally Synthesized and Post-translationally Modified Peptides (RiPPs)

L68 –Y. George Zheng, Panoz Professor of Pharmacy, University of Georgia
Identification of Lysine Acetoacetylation as a Novel Protein Post-Translational Modification

L69 –Ashraf Brik, Professor, Technion-Israel Institute of Technology
Ubiquitin Signaling: Chemistry, Biology and Drug Discovery

L70 –Hiroaki Suga, Professor, University of Tokyo
De Novo Discovery of Pseudo-Natural Products

L71 –Christian Heinis, Associate Professor, EPFL
Membrane-Permeable Cyclic Peptides Against Intracellular Targets and for Oral Delivery

L72 –Louise Walport, Group Leader, Imperial College London and The Francis Crick Institute
Exploiting Covalency in mRNA Displayed Cyclic Peptides

L73 –Scott Miller, Sterling Professor of Chemistry, Yale University
Peptide-Based Catalysis Version 2.0